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Since LGD 4033 is a suppressive compound, testosterone suppression while on cycle is a natural and obvious side effect; however, in men, it should be noted that the reduction of the endogenous testosterone from this period is a negative consequence with regard to the testosterone levels of the other testosterone-secreting tissue such as prostate . In a recent study, T4 and luteinizing hormone (LH) concentrations were lower when LH suppression took place as opposed to when testosterone suppression took place . Although the mechanism of such an effect of testosterone suppression in prostate is uncertain, two important explanations might be possible, but not definitely proven at this point. First, it is thought that this difference between the two sets of data could be due to an effect of decreased LH secretion in the LH-suppressed group  due to the different baseline levels in the two groups. Second, the present study's data clearly shows that testosterone suppression affects LH secretion in the LH-suppressed group, but at the same time, this effect is related with the total testosterone level, which, in a subpopulation of men, can decrease even more than testosterone during the period of testosterone suppression . The main aim of this study was to study the possible impact of testosterone suppression on LH dynamics in the same subpopulation of men, while controlling for the potential impact of other potential risk factors. Subjects/Methods This was a retrospective analysis of all the subjects that entered this study during the period from 1 May of 2009 to 30 June 2013 (see Table 1, Fig. 1A). TABLE 1 Table 1. Subjects for this study. Study Design This was a double-blinded, randomized, placebo-controlled, multicenter design with a crossover design in which a random block of subjects were assigned to either cycle phase 1  or testosterone phase 1 after a 5-week course of cycle phase 1 . No subjects were lost during the course of testosterone phase 1 or any other randomization period or for any other reason. Statistical Analysis The results of this study were assessed using the Student's t-test. Results Figure 1A shows the analysis for cycle phase 1. When comparing baseline values in cycle phase 1 to cycle phase 2 we observed that LH concentration of the LH-suppressed subjects decreased by 5.44% in cycle phase 1 as compared to cycle phase 2 (P = 0.025), whereas all the subjects in cycle phase 1 had decreased LH concentrations as compared to cycle phase 2 by 5.17% (P = 0 Related Article: